tv fjsr � � peg chains had little influence on lithium thionyl battery properties the encapsulation efficiency of methotrexate, but affected the release rate a similar construct between peg chains and ����� was utilized to deliver the anticancer drug fluorouracil encapsulation of fluorouracil into g = ����� dendrimers with carboxymethyl peg surface chains revealed reasonable drug loading, a reduced release rate, and lithium thionyl battery properties reduced hemolytic toxicity compared to the lithium thionyl battery properties nonpegylated dendrimer fig etoposide, mefenamic acid diclofenac, and venlafaxine the combination between dendrimers and hydrophilic and or lithium thionyl battery properties hydrophobic polymer chains has recently been extended to solubilize the hydrophobic anticancer drug etoposide a star polymer composed of amphiphilic block copolymer arms has lithium thionyl battery properties been synthesized and characterized the core of the star polymer was a generation two pamamoh dendrimer, the inner lithium thionyl battery properties block of the arm a lipophilic polyecaprolactone pcl and the outer block of the arm a hydrophilic peg the starpcl polymer was synthesized first by ringopening polymerization of ecaprolactone with the pamamoh dendrimer as initiator the peg polymer was then attached to the pcl terminus by an esterforming reaction characterization with sec, h nmr, ftir, tga, and dsc confirmed the star structure of the polymers lithium thionyl battery properties a loading capacity of up to ww was achieved with etoposide a cytotoxicity assay demonstrated that the starpclpeg copolymer was nontoxic in cell culture citric acidpolyethylene glycolcitric acid cpegc triblock lithium thionyl battery properties dendrimers generations were applied to lithium thionyl battery properties encapsulate small molecule drugs such as mefenamic acid and diclofenac the formulations were stored at room temperature for up to ten months and remained stable with no reported release of the drugs the attachment of the novel thirdgeneration antidepressant venlafaxine onto anionic ����� dendrimers g = via a hydrolyzable ester bond and the incorporation of this drugdendrimer complex into a semiinterpenetrating network of an acrylamide hydrogel lithium thionyl battery properties has been studied as a novel drug delivery formulation to avoid the currently necessary multiple daily administration of the antidepressant the effect of peg concentration and molecular weight was studied to find optimal release conditions ibuprofen, indomethacin, nifedipine naproxen, paclitaxel and methylprednisolone the antiinflammatory drug ibuprofen was used as a model compound to lithium thionyl battery properties study its complexation and encapsulation into generations and ����� dendrimers and a hyperbranched polyester, having approximately surface ohgroups lithium thionyl battery properties it was found that up to ibuprofen molecules were complexed by the ����� dendrimers through electrostatic interactions between the dendrimer amines and the carboxyl group of the drug in lithium thionyl battery properties contrast, up to drug molecules were encapsulated into the hyperbranched polyol the drug was successfully transported into a human lung epithelial carcinoma cells by the dendrimers the ����� dendrimers with lithium thionyl battery properties either amino or hydroxy surfaces entered lithium thionyl battery properties the cells faster in approximately hr than the hyperbranched polyol approximately hrs however, both entries were faster than the pure drug the antiinflammatory lithium thionyl battery properties effect of ibuprofendendrimer complexes was demonstrated by more rapid suppression of cox lithium thionyl battery properties mrna levels than that achieved by the pure drug the nonsteroidal antiinflammatory drug nsaid indomethacin is practically insoluble lithium thionyl battery properties in water and only sparingly soluble in alcohol encapsulation of indomethacin into lithium thionyl battery properties generation ����� dendrimers with amino, hydroxy, and carboxylate surfaces remarkably enhanced the drug solubility in water, and therefore, lithium thionyl battery properties its bioavailability fig warfarin dose adjustment pda the encapsulation efficiency lithium thionyl battery properties of indomethacin into ����� dendrimers is dependent on the dendrimer size g g g g and the lithium thionyl battery properties surface functionalization, nh peg = pyr ae fig the effect of ����� dendrimer generation size and surface functional group on the aqueous solubility, and therefore, bioavailability of the calcium channel blocking agent nifedipine has been studied using ����� dendrimers with eda oi dendrimerconc vw fig molecular structure of lithium thionyl battery properties indomethacin and its solubility profiles in the presence of differing concentrations of gnhz, ?