paclitaxelloaded dqasomes uj day one shot of testosterone a week after tumor implantation fig tumor growth inhibition study in nude mice implanted one shot of testosterone a week with human colon cancer cells the mean tumor volume from each group one shot of testosterone a week was blotted against the number of days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized for paclitaxel, was tripled in all treatment groups empty dqasomes do not show any impact on tumor growth, paclitaxelloaded dqasomes with paclitaxel and dequalinium concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in one shot of testosterone a week the treatment group, after sacrificing the animals days, later was approximately half of that in all controls one shot of testosterone a week although this result seems to suggest that dqasomes might indeed be able to increase the therapeutic potential of one shot of testosterone a week paclitaxel, the preliminary character of this first in vivo study has to be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial one shot of testosterone a week description in , dqasomes and dqasomelike vesicles have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for the therapy of a multitude of mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many helpful discussions overdose of brayer asprins and for his strong and continuous support of my work i also would like to one shot of testosterone a week sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has made the writing of this chapter possible i am obliged to the muscular dystrophy association tucson, az, the united mitochondrial disease foundation pittsburgh, pa, mitovec, inc boston, ma and northeastern university boston, ma for the financial support i received from these organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith one shot of testosterone a week ra, porteous cm, gane am and murphy mp delivery of bioactive molecules one shot of testosterone a week to mitochondria in vivo proc natl acad sci usa murphy mp and smith ra drug delivery to mitochondria the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and one shot of testosterone a week murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria as a pharmacological target pharmacol rev one shot of testosterone a week weissig v mitochondrialtargeted drug and dna one shot of testosterone a week delivery crit rev ther drug carr syst weissig v, cheng sm and dsouza g mitochondrial pharmaceutics mitochondrion weissig v targeted drug delivery to mammalian one shot of testosterone a week mitochondria in living cells exp opin one shot of testosterone a week drug del weissig v, boddapati sv, one shot of testosterone a week dsouza ggm and cheng sm targeting of low molecular weight drugs to one shot of testosterone a week mammalian mitochondria drug des rev de one shot of testosterone a week rosa m, gambacorta a and gliozi one shot of testosterone a week a structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev gambacorta a, gliozi a and de rosa m archaeal lipids and their biotechnological applications world j microbiol one shot of testosterone a week biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations of dqasomes proc intl symp control rel bioact mater weissig v, lizano � and torchilin vp a micellar one shot of testosterone a week delivery system for dequalinium � a lipophilic cationic drug with anticarcinoma activity j lipos res weissig v, lizano c, ganellin cr and torchilin vp dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study one shot of testosterone a week stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy for mitochondrial dna defects is it possible?