if nanoparticles enter cells, is there an effect on cellular vegetables you cant eat on coumadin functions quality of materialcharacterization as new toxicological risks that derive from novel materials and delivery systems are identified, new tests will be vegetables you cant eat on coumadin required to ascertain safety and efficacy industry and academia need to vegetables you cant eat on coumadin plan and conduct the research to identify potential risks and to vegetables you cant eat on coumadin develop adequate characterization methodologies what are the forms in which particles vegetables you cant eat on coumadin are presented to host, tissues, organs, organelles and cells what are the critical physical and chemical properties, including residual solvents, processing variables, impurities and excipients what are the standard tools used for this vegetables you cant eat on coumadin characterization what are the validated assays to detect and quantify nanoparticles in tissues, medical products, foods and processing equipment how do physical characteristics impact product quality and performance how do we determine long vegetables you cant eat on coumadin and shortterm stability of nanomaterials en vironmen tal considera hons can nanoparticles be released into the environment following human and animal use what methodologies would identify the nature and quantify the extent of nanoparticle vegetables you cant eat on coumadin release in the environment what might be the environmental impact on vegetables you cant eat on coumadin other species eg animals, fish, plants, microorganisms as the materials and vegetables you cant eat on coumadin the techniques used to manufacture the novel formulations may not have prior art to refer to as a standard, there is an additional burden on the pharmabiotech industry to carry out a detailed vegetables you cant eat on coumadin evaluation of the system to generate sufficient database for successful industrialization vegetables you cant eat on coumadin of the product some of the industrially relevant criteria include understanding the relationship between the physicochemical properties and product performance, effect of process and formulation variables on product characteristics, development of analytical tools and specifications to regulate product quality, accelerated stability testing as per vegetables you cant eat on coumadin standard protocols to propose a reliable shelflife, product scaleup to mass production and establishment of manufacturing standards and development of reference materialsstandards vegetables you cant eat on coumadin as guidelines for quality assurance development of validated testing methodsprotocols and establishment of reference standards through a thorough and logical process remains to be the major responsibility of the industry for convincing the fda vegetables you cant eat on coumadin to get product approval while considering the application of a polymeric nanoparticlesbased formulation, the fda may want the industry to include evidence vegetables you cant eat on coumadin for the parameters listed below particle size and size distribution surface vegetables you cant eat on coumadin area, surface chemistry, surface coating and porosity hydrophilicity and surface charge vegetables you cant eat on coumadin density purity and quality stability on shelf and upon administration manufacturing vegetables you cant eat on coumadin and controls drug release parameters and bioequivalence testing considerations conclusion and outlook under the light of current literature ie articles, books, patents vegetables you cant eat on coumadin and information posted on the nanotech company websites and the product vegetables you cant eat on coumadin pipelines of leading pharmabiotech companies, it is evident that we would be seeing many nanotechnologybased pharmaceutical products in this century table lists few of the important products in the drug delivery pipeline that vegetables you cant eat on coumadin are based on polymeric nanoparticles it is likely that the oral formulations would dominate this specialized segment of novel dosage forms the chemicalpolymer industry has been feeding the drug delivery scientists with a variety of biopolymers, having wide range of specialized properties nanoparticles made from the biopolymers are likely to dominate the novel drug delivery systems in the oral market because of the costtobenefit ratio, excellent stability, flexibility for industrial production and a voluminous database available, with respect vegetables you cant eat on coumadin to the regulatory issues addressed earlier polymeric nanoparticles are also being vegetables you cant eat on coumadin explored for topical applications and as sterile dosage forms for ophthalmic, nasal, subcutaneous and intravenous applications there are several other potential nanoparticles technologies which fall outside the coverage of this chapter, which are vegetables you cant eat on coumadin based on nanoparticles made from the drugs themselves they are termed as nanosuspensions, nanocrystals or insoluble drug delivery technologies essentially, all of them are colloidal dispersions of pure drug particles that are stabilized by polymers, surfactants or lipids they are synthesized either by physical vegetables you cant eat on coumadin eg size reduction by milling or chemical eg change in solubility induced by ph or solvent exchange means in the presence of stabilizing vegetables you cant eat on coumadin agents the striking advantage of these technologies is the high drug loading efficiency and the simplicity associated with its production these have vegetables you cant eat on coumadin been the first to roll out from the research and development vegetables you cant eat on coumadin scale to the industrial production scale under nanoparticle category rapamune� oral solution and tablets table product pipeline of polymeric nanoparticles source pharmaprojects technology bioactive compound company route of delivery france of amino acids vegetables you cant eat on coumadin bioalliance, france polyisohexyl doxorubicin intravenous cyanoacrylate nanoparticles munich biotech drug nanoparticles paclitaxel intravenous germany biosante, usa calcium phospahte insulin oral nanoparticles targesome, usa selfassembling lipid therapeutic intravenous nanospheres diagnostic american albumindrug paclitaxel intravenous vegetables you cant eat on coumadin bioscience, usa nanoparticles advectus life polybutylcyanoacrylate doxorubicin intravenous sciences, canada nanoparticles nanocarrier, japan micellar nanoparticles water insoluble drugs wyeth drug nanoparticles rapamycin oral novavax, usa flamel technologies micellar nanoparticles medusa� nanoparticles testosterone insulin interferon subcutaneous subcutaneous pharmaceuticals, usa containing sirolimus from wyeth and sangcya� vegetables you cant eat on coumadin oral solution from sangstat corporation containing cya if the science of pharmaceutical product development is undergoing a transformation from a traditional pharmaceutics to vegetables you cant eat on coumadin a more innovative molecular or nanopharmaceutics, the major credit would be vegetables you cant eat on coumadin taken by a combination of polymer based systems and nanoparticles it is more of a belief than a hope that the polymeric vegetables you cant eat on coumadin nanoparticles would address many of the therapeutic issues that are posing vegetables you cant eat on coumadin hurdles to a formulation scientist in this century references wilson � and waugh a anatomy and physiology in health and illness churchill livingstone new york tortora g and anagnostakos n principles of anatomy and physiology harper and row new york tate p, seeley r vegetables you cant eat on coumadin and stephens t understanding the human body mosby st louis solomon e introduction to human anatomy and physiology w b saunders company, philadelphia mcclintic jr basic anatomy and physiology of the human body john wiley and sons new york ganong w review of medical physiology appleton and lange norwalk, ct shojaei a buccal mucosa as a route for systemic drug delivery a review j pharm pharma sci vegetables you cant eat on coumadin zhang h, zhang j and streisand jb oral mucosal drug delivery clinical pharmacokinetics and therapeutic applications clin pharmacokinet collins l and dawes � the surface area of the adult human mouth and thichness of the salivary film covering the teeth and oral mucosa } vegetables you cant eat on coumadin dent res harris d and robinson j drug delivery via the vegetables you cant eat on coumadin mucous membranes of the oral cavity, f pharm sci sakuma s, hayashi m and akashi m design of nanoparticles composed of graft vegetables you cant eat on coumadin copolymers for oral peptide delivery adv drug del rev gandhi rr, j oral cavity as a site for bioadhesive drug delivery adv drug del rev florence at particulate delivery the challenge of cefuroxime axetil drug interactions the vegetables you cant eat on coumadin oral route drugs pharm sci jung t, kamm w, breitenbach a, vegetables you cant eat on coumadin kaiserling e, xiao jx and kissel t biodegradable nanoparticles monthly use of ultram for oral vegetables you cant eat on coumadin delivery of peptides is there a role for polymers to affect mucosal uptake?